those pills for a week thinking,
‘am I ready for this?’
“After a week I started taking them and they were awful. I
was taking pills four times a day. I spent the first year on the
drugs feeling sick all the time - diarrhoea, the usual things.
“Nowadays most regimes
are much simpler and easier to take, but back then most drug regimes
were three times a day and you had to really concentrate on taking
them on time. But I was very good and never missed a dose. The drugs
did the trick and my viral load came down to undetectable. So I
persevered and I was prepared to put up with the side effects.
“Some time after I moved back to the UK in 1998 I was talking
to my doctor and I commented on how the veins were showing in my
legs. I’d lost all the subcutaneous fat and wondered whether
I was getting that ‘sunken-cheek’ look. We talked through
the options, what drugs might be responsible. One option was to
stop taking the drugs altogether and wait and see what happened.
So I stopped with the expectation that there could be some viral
rebound.
“About two weeks after I stopped taking the drugs, I woke
up one morning thinking how well I felt. I’d got so used to
feeling bad for four years and after stopping I felt fantastic so
I’ve stayed off the pills ever since.”
Why do you think your immune system is fighting back without the
drugs?
“I put it down to my state of mind. I’m much happier
with myself these days. I’ve done a lot of therapy and
I think that has helped.”
Are you worried about drug-resistant HIV?
“All of this is really uncharted territory. Treatment interruption
is a very broad term but in my case it paid off. I feel much better
and it hasn’t caused me any problems. We were very careful
about the sequence of how and when we stopped the drugs because
of different concentrations and half-lives to make sure there wasn’t
a single drug floating around in my system. But I must stress that
although I am trained as a doctor and work for GSK, I am not an
HIV specialist.”
Many people have a perception of pharmacos pushing their products
to make a profit and encouraging people to go on treatments.
“The big picture is that people need to be encouraged to test
and
take treatments when it’s
appropriate, but I don’t think Glaxo